This may explain why we hardly ever seen in MS families for three generations, he said.The study could also broaden the understanding of how environmental influences modify the genes to cause a wide range of diseases.
The theory is that as environmental influences, as well as sun exposure can change gene expression and the expression of the gene modified is passed from one generation or two.
The causes of multiple sclerosis are not well understood, but experts have long suspected that environmental factors trigger the disease in people who are genetically predisposed.
Disease rates are higher among people living farthest from the equator, and there is widespread speculation that the lack of a result of sun exposure may explain this low.
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Several research teams Ebers, Orhun Kantar, MD, the Mayo Clinic in Rochester, Minnesota, is one of the few research studying the epigenetic about multiple sclerosis.
Women were also more likely to transmit the mutation to their daughters that their child and more likely to share the MS susceptibility gene more distant female members of the family.
The study was published online today, and also appears on the January 18 issue of Neurology. Genetic alterations
The idea that the environment would change gene that was once considered ridiculous, Ebers said. Now that is trying in this way is a major influence on the disease that we never imagined.
Kant called the new research a potentially important piece of the puzzle to explain the gender difference in MS, but adds that the research must be replicated.
They found that women with MS were 1.4 times more likely than men with the disease carry the gene variant linked to risk of disease.
New research could help explain why rates have risen dramatically in the United States and other countries among women, while rates appear stable among men.
A total of 919 women and 302 men were given the variation in the MHC region, compared to 626 women and 280 men who did not.
Ebers research suggests that the ability of environmental factors to alter gene expression – a relatively new field of genetic research known as epigenetics – plays a key role in multiple sclerosis and that this role is between a man and woman.
Although it is not clear what’s to blame for the growth, the study authors believe it is unlikely that in vitro fertilization is the cause of the increased risk of cancer.
Epigenetics is changing.
Genetic alterations related to environmental insults can be transmitted from one generation or two, but the DNA usually right over time, Ebers said.