The new research appears in the September issue of Archives of Neurology.The researcher Consuelo Wilkins, MD, tells WebMD that a better understanding of weight loss before the development of Alzheimer-related dementia may help researchers in their efforts to identify the disease earlier.
Thin acceleration of weight loss that can accompany aging may be an early warning sign of Alzheimer’s disease, new research suggests.
We get insights into what happens with the brain in pre-symptomatic dementia occurs before, said David K. Johnson, PhD. The speed Past High ‘
Early detection is important because the drugs that we have to treat Alzheimer’s disease can slow the course, he said. The treatment is begun early, the better.
This study was supported by grants from the National Institute on Aging.
During the study, 125 people developed dementia related to Alzheimer’s disease. Those who weighed an average of 8 pounds less than those who do not have the beginning of the study.
Among patients already diagnosed with Alzheimer’s dementia, rapid weight loss has long been associated with more rapid progression of the disease. But during the weight loss before the development of memory loss and other symptoms of dementia has not been well understood.
No matter what we did to control the variables of health, such as diabetes, stroke, hypertension, none of them could explain this effect, says Johnson.
There were no significant differences in appetite in Alzheimer patients and the future of those who did not develop dementia in the study reported recently.
Elderly in a study who were followed for an average of six weight lost twice in the previous year the first signs of dementia seems to be people who did not develop dementia associated with Alzheimer’s – 1.2 pounds compared to a loss of weight of 0.6 pounds per year.
Somewhere between the last evaluation when they were healthy and this first evaluation when they had mild dementia, a metabolic process kicked and kicked into high gear, and made their Alzheimer’s detectable weight loss. It is more than kept pace with this change. More studies needed
The researchers used data from memory and Aging Project at the Center for Alzheimer’s Disease Research at Washington University in St. Louis, which is a long-term study to evaluate the impact of aging on the brain.
The study is the first to suggest a link between weight loss and the development of Alzheimer’s disease.
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In early 2005, a long-term study involving 1,800 Japanese-American men followed for 32 years has found that older men with dementia lost an average of 10 percent of their body weight in the years before they were diagnosed.