‘Patients with gallbladder cancer continue to have a poor prognosis, because most patients present with advanced disease,’ the authors write. ‘Early diagnosis combined with aggressive surgical approach gives better results. A better understanding molecular pathways that contribute to the development of cancer of the gallbladder is the need for better adjuvant therapies to increase overall survival.’Overall median improved the survival of 3.5 months in period A to 6.5 months in period B and 12 months in period C. ‘The stage of disease at presentation influenced the survival of all ages ,’ the authors write . ‘The survival of patients with advanced disease receiving palliative care [for treating symptoms only] procedures remained poor in all periods
Ioannis T. Konstantinidis, MD, Massachusetts General Hospital and Harvard Medical School in Boston and colleagues identified 402 patients with gallbladder cancer in a university-affiliated tertiary care center between 1962 and 2008. Of these, 260 underwent surgical exploration at the same institution and were included in the analysis.
It is estimated that about 9520 new cases of cancer of the gallbladder or biliary tract were diagnosed in the United States in 2008 and about 3340 of these patients die of their disease, according to background information in the article. The disease affects women more frequently than men, and surgical removal of diseased parts of organs is the only cure. ‘Cancer of the gallbladder is characterized by locally aggressive behavior, with the spread early to lymph nodes and distant spread,’ the authors write. ‘Also, it’s fast, after the supposed curative resection.’
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