TOF PET images compared to conventional PET images: Improved detection, better for patients

The authors of the scientific paper, ‘Improving the detection of lesions of the whole body oncologic PET time of flight’ include: Georges El Fakhri and Cathryn M. Trott, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School and Massachusetts General Hospital, Boston, Mass., and Suleman Surti, Joshua Scheuermann and Joel S. Karp, Department of Radiology, University of Pennsylvania, Philadelphia, PennsylvaniaImproved detection of lesions was observed in the TOF PET, the most profitable in the shorter studies of acquisition and those with a BMI of 30 or more. Also note – the largest gain in performance was achieved at the lower contrast of the lesion and the smallest increase in performance with the highest lesion contrast.

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Conventional PET create images by detecting gamma rays produced by radioisotopes that are injected into the body. Although these conventional analyzes to track gamma rays, where to go, do not consider the time taken for each gamma ray to reach the detector. TOF PET does not take into account the travel time, resulting in improved image SNR.

To create a clinical trial experienced an injury while ensuring a perfect knowledge of the presence and location of each lesion, 10 mm spherical lesions were added to positions in bed free of the disease, resulting from the merger this lesion studies. These studies appropriately corrected for attenuation of the body so that the presence or absence of lesions was similar to studies on actual patients.

The technicians and nuclear medicine physicians may be able to exploit the gain with TOF PET to reduce scanning time, which increases patient comfort and minimize patient movement.

They may also be able to reduce the dose of radiopharmaceutical injected, thus reducing the exposure of patients and healthcare workers to radiation.