Thesis describes 35 previously unknown families of endogenous retroviruses, after analysis of cattle and horses

M. Koldo Garcia Etxebarria has a degree in biology. He pitched his doctoral thesis under the direction of Mrs. Marina Jugo Bego a Orrantia, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology of the UPV / EHU. Garcia worked at the Institute of Evolutionary Biology in Barcelona. Part of the conclusions of the thesis were published in the October issue of the Journal of Virology, the fourth publication in the world dealing with virology.M. Garcia took a more detailed investigation in the case of cattle, also focusing on genes surrounding the VRE, in other words, in the context of genomics. As stated in the thesis, most of the genes close to ERVs are associated with protection against viruses and histones . According to the researcher, this could be due to the genes to be activated when retroviruses are introduced, or because they have recognizable features

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M. García use of computer tools to detect VRE. As a result, a total of 35 families of ERV , not mentioned in the literature, have been detected, concrete, 24 families can VRE in cattle, of which 20 have not been described experimentally. Of these, M. BoERV1 Garcia family, of course, is the most abundant among those found. As stated in the thesis, may be the case that a family of specific ERV ruminants. As for horses, possible 15 families were detected, none of them described to date.

The researchers also studied how ERV proliferation in both species and concluded that reinfection is the most common method in both cases. In general, ERV proliferates in two ways: by transposition or re-infection . The thesis shows that re-infection is very common, as well as the spread is more common in many other animals.

García data collected on humans, chimpanzees, mice, rats and dogs for research, compared with that of cows and horses and has shown that except for mice, these animals use a new infection of more than transposition.