When the specific causes of kidney disease were analyzed, the children whose mothers had diabetes before pregnancy had an increase of almost 700 percent risk of birth defects related to the kidneys (renal aplasia / dysplasia). “Anomalies in the development of the urinary tract are the most common cause of chronic renal failure of childhood,” said Hsu.The new results suggest the possibility that a stricter control of diabetes and weight control during pregnancy may reduce the risk of development of children with chronic renal failure. “However, this should be considered in future research,” says Hsu.
“Prenatal risk factors for chronic kidney disease in children,” [SA-FC358] was presented as an oral presentation at the Colorado Convention Center in Denver, CO
The overall rate of childhood chronic kidney disease was about 0.26 percent – about 1 in 400 live births. When the researchers adjusted for the duration of gestation, the risk of chronic kidney disease was 69 percent higher for children whose mothers had diabetes before pregnancy. For children whose mothers developed diabetes during pregnancy (gestational diabetes), there was an increase of 28 percent increased risk of chronic renal failure. Children of obese mothers showed an increase of 22 percent of the risk of chronic kidney disease.
In adults, chronic renal failure is often linked to diseases such as diabetes and l ‘. However, according to Hsu, “Development of childhood chronic renal failure can be programmed before birth.” Few studies have examined possible risk factors for developing chronic renal failure before adulthood.
The risk of urinary blockage (obstructive uropathy) – which can lead to chronic renal failure – has increased by 34 percent for children whose mothers had gestational diabetes, 23 percent in those whose mothers were obese, and 21 percent in those whose mothers were overweight but not obese.
The study involved over 4,000 patients with CKD childhood – diagnosed at the age of 21 or less – in Washington State. These patients were compared with more than 20,000 healthy children to evaluate the possible relationship between a pregnant woman with diabetes, obesity or overweight, and the risk of developing childhood chronic renal failure at any time during childhood, in ‘ childhood or adolescence.
The study has some limitations related to the fact that he used Washington State birth records linked to a database of hospital discharge. As a result, could not identify children with chronic kidney disease who were hospitalized and kidney disease are listed in their hospital discharge diagnosis. The IRC definition of the study was also large, and the results were reanalyzed with a more stringent definition CKD. In addition, conclusions regarding the causes and effects are not possible due to the design of case-control study.