A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for diseases of the liver.The technology of mobile broadband network used in this research was developed by Chien and colleagues in the lab a few years ago mainly for stem cell research, but has not been applied to this type of research before involving hepatic stellate cells.
‘Looking at the table, you get hundreds of different combinations of protein and you can watch hundreds of cells at once,’ said Brenner. ‘This will give us new perspectives for the treatment of liver fibrosis and will give us the platform to test new treatments. It also allows us to do critical experiments that will assess the ability of different drugs to work. There is no truly effective therapies for fibrosis there is only one liver transplant. This is a big step forward. ‘
Approaches underway to identify factors that influence HSC biology typically focus on each individual factor, ignoring the complex cross-talk between the many components that act on cells. The technology of mobile broadband network developed by UCSD researchers systematically examines and probes the complex relationship between hepatic stellate cells and components of their microenvironment. In this way, they discovered that certain proteins are critical in regulating HSC activation and proteins that affect every other action on the cells. The results were published in September 2009 of Integrative Biology
‘In one step, we look at the physical and chemical microenvironment of cells,’ said Chien. ‘Now we can look at the optimal condition is best for the cells to proliferate and differentiate.’
‘Our laboratory is interested in cells that have the responsibility to fix the fibrous scar in all types of chronic liver disease,’ said Dr. David Brenner, dean of the Faculty of Medicine at UCSD and co-authored the paper. ‘Over the past 20 years, people have tried three or four dice to try to optimize their growth. Shu Chien mentioned this picture of the extracellular matrix that his lab has used stem cells, and I thought it would be an incredible opportunity to understand the effects of different matrices in primary cell cultures
In this paper, the researchers used a system table that identifies the biological components that can lead to mitigate or liver disease. The technology works by controlling the range of environments surrounding the hepatic stellate cells called hepatic stellate cells .
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HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.