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Researchers in dental tissue engineering at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have exploited the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and mucosal Oral (moist tissue that lines the inside of the mouth).

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These tissues are modified very similar to their human counterparts and can be used to address the concerns of the main field of stem cell biology that are related to their clinical use. We can now use these fabrics designed as replacements for tissues begin to predict how stable and safe hESC-derived cells after transplantation is therapeutic. Our goal is to produce functional tissues to treat diseases of the oral cavity and skin, as the early stages of cancer and inflammatory diseases and to accelerate the healing of recalcitrant wounds Garlick said.

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The researchers looked for ways to grow as skin tissue outside the body using new sources of stem cells such as hESCs, with the goal of advancing regenerative medicine as a new therapy to replace or repair damaged or diseased tissue . Little is known about how hESC can be developed multilayered tissue similar to those that line the gums, cheeks, lips and other areas in the mouth. We used in vitro tissue engineering to produce tissues such as skin that mimic the tissue that lines can be found in the oral cavity, said Garlick.

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