There are many children who are doing good in school and for whom this is not going to be a problem, but there are a great number of children who are teetering about the academic edge, Clarkin said. This may be the difference between them graduating and making something of themselves, versus dropping off the rails. But while he agrees generally there must be increased regulation that helps to keep e-cigarettes out from the tactile hands of teens, Clarkin said that regulation only won’t stop this.The 12-month survival rate was 58.1 percent . The confirmed response rate was 33.3 percent. Related StoriesStudy looks at survival benefits of surgical resection for melanoma sufferers with abdominal metastasesNew findings reveal association between colorectal cancer tumor and melanoma drug treatmentUCSF-led experts map out melanoma's genetic trajectoriesIn the temozolomide arm, patients received a median 4-cycles of therapy . The 6-month PFS rate was 32 percent . Median PFS for patients in the temozolomide arm was estimated at 3.8 months and the median OS was 12.3 months.