Potential new way to protect the kidneys threatened by insufficient blood or toxins

Acute renal failure, a disease with high mortality, is increasing due to the increased incidence of cardiovascular disease, diabetes and other health problems that prevent the kidneys to get enough blood.Dr. Dong and his colleagues used an inhibitor of the mitochondrial fission process using natural increase. One of his goals is to develop safer, more effective drugs can be administered to patients with acute renal failure.

Best treatments for acute renal failure may be possible through the blockade of mitochondrial fragmentation that occurs when the kidneys do not receive enough blood or are exposed to toxic substances, researchers at the Medical College of Georgia report in the May issue of The Journal of Clinical Investigation.

‘When mitochondrial fragmentation is blocked, you can save and kidney cells,’ he said.

The fragmentation sets in motion a chain of events that leads cells to commit suicide and kidney leads to acute renal failure.

Other authors of the books of study, Dr. Craig, former MCG graduate student now a postdoctoral fellow at Harvard University Brigham and Women Hospital, Dr. Qingqing Wei, MCG, researcher, and Cho Sung-Gyu, an MCG graduate student.

A further advantage is the electrical conductivity of the new material, which can also be used in electrodes for mechanical actuators, energy storage, and sensors. For example, the researchers were able to produce a hydrogen peroxide sensor. Carbon nanotubes catalyze the oxidation of hydrogen peroxide, resulting in a measurable current. Hydrogen peroxide plays a role in normal cardiac function and heart disease. A robust sensor with elasticity similar to the heart muscle would be of great help in researching these relationships

In addition to acute renal failure, Dr.

Dong believes fragmentation inhibitors can improve the preservation of kidneys extracted from a donor for transplantation.