The study also revealed a new biological pathway for the development of the disease AMD and found two genes associated with risk of AMD in the high-density lipoprotein cholesterol path: human hepatic lipase and the transfer protein cholesterol ester . Scientists have identified two additional genes, lipoprotein lipase and ATP binding cassette transporter 1 , which may be involved in the way of cholesterol as well, but more research is needed to confirm these results.The Office of Technology Commercialization at Purdue Research Foundation has applied for U.S. patent on the concept.
A large genetic study of macular degeneration has identified three new genes associated with this blinding eye disease – is involved as cholesterol. The results of this collaborative study on a large scale, supported by the National Eye Institute , part of the National Institutes of Health, were published online April 12 in Proceedings of the National Academy of Sciences.
AMD is a leading cause of visual impairment and blindness in older Americans. The researchers discovered the genes that represent a significant risk of AMD through the genome-wide association studies , which scans the whole DNA of individuals to find genetic variations linked to certain diseases.
The last large GWAS was led by Anand Swaroop, Ph., currently head of the NEI Neurobiology-Neurodegeneration and Repair Laboratory, Gonçalo Abecasis and D. Phil.
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, Professor of Biostatistics at the University of Michigan, Ann Arbor.