Researchers at the University of British Columbia, the University of California, San Francisco and the Medical University of Graz, Austria contributed to this work. Financial support was provided by NIH, the Melanoma Research Alliance, the Canadian Institutes of Health, the Canadian Cancer Society, the European Commission and the Oesterreichische Nationalbank Jubilaeumsfonds.In addition, said Dr. Bastian, ‘since the vast majority of mutations in both uveal melanoma harbor oncogenes, suggesting that activation of Gq/11 is the main route for the development of uveal melanoma and identifies a new target for ‘therapeutic intervention. ‘
The reduction of 5 % in skeletal related events, including pathologic fractures and spinal cord compression observed in the denosumab compared with zoledronic acid group is very encouraging, Kavalerie said. It is a difficult population of patients that their symptoms associated with bone metastases can be debilitating.
An, an international multicenter study has revealed the discovery of a novel oncogene that is associated with the uvea, the most common form of the eye. Researchers have isolated an oncogene called GNA11 and found that in more than 40 % of tumor samples from patients with uveal melanoma.
The findings are published early online November 17, 2010 in New England Journal of Medicine and will appear in the December 2, 2010 Print,.