Overall, the new drug looks very promising, he said. There’s more recognition of the problem of severe refractory gout and a large number of people working on different approaches to anti-inflammatory and to lower uric acid level, he said.In the new study of 10 people with severe, chronic gout, participants received two weekly injections of a drug followed by six weekly injections of rilonacept fictitious. In the second to eighth week of the study, 70 percent had at least a 50 percent improvement in their pain, 60 percent had an improvement of at least 75 percent in their grief. However, none of the participants showed improvement while receiving sham injections.
It ‘really rewarding to see patients who are considered the worst of the worst response, said Terkeltaub. If it works, in the worst of the worst, we hope that work in the least worst of the worst .
The results were presented at the American College of Rheumatology Annual Scientific Meeting in Boston.
Uric acid is found naturally in the body. In gout, there is usually a problem with the excessive production of uric acid or problems in getting rid of uric acid, or both. During an attack of gout is usually treated with drugs that cool inflammation. In addition, uric acid-lowering drugs are sometimes prescribed
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Terkeltaub is section head of rheumatology, allergy, VA Medical Center in San Diego and a professor of medicine at the University of California at San Diego. Now we can help break the inflammatory cycle in these patients, he said.
Many patients with gout may not take the standard anti-inflammatory drugs such as nonsteroidal anti-inflammatory drugs , colchicine, or systemic steroids, as they may have kidney problems, heart problems or diabetes, says researcher Robert Terkeltaub , MD.
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Administered by injection just under the, rilonacept blocks interleukin-1, a protein involved in inflammation. A new study of 10 people with a severe drop shows that significantly reduces disease activity and two.
Michael Hershfield, MD, professor of medicine and biochemistry at Duke University School of Medicine in Durham, North Carolina, tells WebMD that a drug like this or any other that blocks IL-1 may prevent eruptions that occur when we have a dramatic effect in reducing levels of uric acid. Both can work well together. Hershfield developed a new uric acid lowering drug called PEG-uricase, which is currently in clinical trials.
A new drug could fight inflammation relief for sufferers of severe gout who can not take other medications for the treatment of gout because of health problems behind.