But this additional study was necessary because it was thought that the progression of the disease may be different in African children.Among children, 2713 were treated with artesunate and quinine with 2713. There were 230 deaths in the artesunate group and 297 deaths in the quinine, the study authors reported.
The study’s authors, Nicholas White of Mahidol University in Bangkok, Thailand, and colleagues AQUAMAT study group also noted that while artesunate is more expensive to buy, quinine is more expensive to manage.
Malaria, a disease that is transmitted through the bite of an infected mosquito, can quickly become fatal if not treated, according to the World Health Organization.
If 4 million African children with severe malaria each year would receive immediate treatment with parenteral artesunate instead of quinine, and the benefits were similar to those recorded in this process and about 100 000 lives could be saved each year, they concluded.
This means that the risk of death was 22.5 % lower for children who received artesunate. The investigators also found that side effects such as seizures and coma were less frequent among those given artesunate.
A previous study has shown that the mortality rate of malaria in Southeast Asian adults treated with artesunate was 14 % against 23 % for those treated with quinine. Following this study, the World Health Organization has changed its guidelines to recommend artesunate for severe malaria in adults.
The study was published online in advance of publication in an upcoming print edition of The Lancet, has been set for Saturday presentation at a meeting of the American Society of Tropical Medicine and Hygiene, held in Atlanta.
Before ordering a CT scan, Spevak says doctors should ask yourself the following questions: ‘And ‘this is the right test for this condition’ and ‘Can I have the answer in another way’ If the answer to the first question is yes and the answer to second question is no, the next question should be: ‘What is the minimum dose that will give me the answer?’
The results suggest that artesunate should replace quinine as a treatment for malaria recommended for severe malaria worldwide, the researchers said.
The U. S.
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Centers for Disease Control and Prevention has more about malaria.