The dog has the fifth donor stem cells have shown no improvement or setback, and the sixth showed modest deterioration in his condition.The study is the first to explore the role of NGF on cardiac cells in health and healing, rather than its influence on cardiac nerves.
The first group consists of three dogs that received no shooting of stem cells. They worsened muscular dystrophy.
The donor stem cells, seemed to be more effective stem cells genetically twisted, the researchers write.
The latter group includes four dogs are up to five shots of their stem cells that had been optimized to make the most of dystrophin, a protein missing in Duchenne muscular dystrophy. Conflicting results
Duchenne muscular dystrophy is one of nine major types of muscular dystrophy. This is the most common form of muscular dystrophy in children, and affects only males.
Two of six dogs who donated stem cells were able to walk, one of whom was able to run at the end of treatment.
Among these Giulio Cossu, MD, Institute for Stem Cell Research in Milan, Italy.
The strategy calls for more work. But the group Cossu said that their study establishes the logical assumption to begin clinical trials for Duchenne muscular dystrophy.
Lab tests on dogs show that adult stem cells may help treat a certain type of muscular dystrophy, say Italian researchers in the journal Nature.
In human muscle dystrophy, the muscles weaken over time. Many patients eventually need wheelchairs, most die in their late teens or 20 years. Study of stem cells
As with any transplant unless the donor and recipient were immunologically matched, the recipient must be placed on lifelong immunosuppression is not always effective and can have unpleasant side effects, Chamberlain wrote in the journal Nature.
Cossu’s team has divided the dogs with muscular dystrophy in three groups.
The results are different, but dogs that have been donation of stem cells in general faired better.
He added that it would be preferable to give each patient’s stem cells genetically corrected, if the technique can be made more effective.
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The second group of six dogs who received five shots of the donor stem cells from healthy dog with drugs to help their immune system to accept these cells.