In a paper published this week, the group describes the interactions between sister kinetochores just discovered – the bundles of proteins at the contact point between the two identical strands of a chromosome – and microtubules, the strings that attach to the kinetochores to pull the wires apart.To do this, the group has developed an innovative range of preparation and photographed by dividing human cells, and the calculation of image analysis to quantify the interactions between sister kinetochores in three dimensions.
Swedlow MBL employees in this job, which will continue during the summers to come, including the science laboratories of Prof. Gaudenz Danuser (Harvard Medical School), Dr. Patrick Esmeralda (ETH Zurich, Switzerland) and Dr Andrew McAinsh (Marie Curie Research Institute , England). The group is known as the MBL Consortium kinetochore.
We believe we have developed new methods and acquired knowledge that is simply not available anywhere else. We could not do this work anywhere except at the MBL, says Jason Swedlow, a professor at the University of Dundee in Scotland.