Vitamin D is produced in the body in response to exposure to direct sunlight, and all that limits the exposure also limits the amount of vitamin D produced by one person.‘If we can understand why, we might be able to improve the treatment of these patients,’ said neurologist Bruce Cree, MD, PhD, another author of the paper and one of the leading researchers.
‘There are probably other factors that determine the severity of the disease, including genes and other environmental factors like smoking,’ said Jeffrey Gelfand, MD, lead author of the study. Work is currently underway to determine how genetic differences may influence the severity of multiple sclerosis.
Vitamin D alone could not explain this apparent difference in severity, the study found.
The previous work of the UCSF team determined that the same African-Americans tend to become quickly disabled with multiple sclerosis, often having to rely on canes and wheelchairs.
Tracheotomy is a surgical procedure that is performed to replace the endotracheal intubation in patients who are expected to require mechanical ventilation prolonged. late after larynx allow intubation reduce the incidence of VAP and increase the number of the department and no fan days off.
Multiple sclerosis is a chronic disease where the immune system attacks a person legally myelin sheaths that insulate nerve fibers in the brain and spinal cord. The damage to the sheaths can short circuit signals traveling along the nerve fibers, disrupting the normal flow of communication between the brain and causes a variety of symptoms such as weakness, sensory disturbance, fatigue, visual disturbances and loss of coordination.
This large cohort of African-Americans with MS was used to compare 339 African Americans with multiple sclerosis to those of a group of 342 African-Americans who have not had the disease. Although vitamin D deficiency was very high in both groups, those with multiple sclerosis were more likely to be deficient in vitamin D 77 % vs. 71 %.
Published this week in the journal Neurology, the study results are consistent with observations in Caucasian populations that link low vitamin D levels for multiple sclerosis. However, the research could not explain why MS tends to be more severe in African-Americans, even if the disease is less common in the Caucasian population.
Researchers at the UCSF Multiple Sclerosis Center have been investigating for several years as the genetic and environmental factors such as low levels of vitamin D may make people susceptible to MS.
These same questions were more difficult to assess African American populations, however, because the prevalence of vitamin D deficiency is extremely high among all African-Americans.
Previous studies have shown a dramatic relationship between the levels of vitamin D and multiple sclerosis, but only in Caucasians. Caucasians living in tropical or subtropical climates are less likely to be diagnosed with multiple sclerosis than those who live in temperate climates.
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The prevalence of the disease in North Dakota, for example, is about twice that in Florida.