‘Live’ image reveals the transition of breast cancer cells “in the metastases

We know surprisingly little about how cancer cells spread through the body, because it is incredibly difficult to study, said Sahai.While the individual cells can travel through the bloodstream to sites throughout the body, groups of tumor cells are confined to the lymphatic system, which keeps them local.

The spread of individual tumor cells is more deadly is the metastasis of a group of cells.

Messenger These genes may be a promising target for drugs to block the road with metastatic breast cancer, said Erik Sahai, PhD, Cancer Research UK in London.

The results helped us to find all the genes behind the spread of breast cancer – and that the genes must first be turned on and off for individual cells can move an Sahai said.

Because tumor cells were labeled with protein reporters that glowed blue when the phone messaging system TGFb was active, the researchers determined that breast cancer cells only broken with the main tumor and entered the bloodstream when TGFb first power of the messenger genes in cancer cells and then turned off.

The spread, or metastasis, of individual cells of the primary tumor into the blood to the lungs and other body tissues and organs is under the control of an abstract growth factor TGFb, according to a study on laboratory mice that was presented at the American Society for Cell Biology 49th Annual Meeting, 5 to 9 December 2009 in San Diego.

Presentation Sahai ASCB conference in October 2009 following the publication of the study in Nature Cell Biology.

In a medium-sized tumor could be a billion cells – and only a small part could break, and pouring So it’s like trying to find and understand -. – a needle in a haystack moving very large.

But, when TGFb was inactive, clumps, not the individual cells of breast cancer has been separated from the main tumor. Why are these groups that can spread through the lymphatic system, the metastasis was local, not blood.

Investigators conducted this phase III study in an IDE approved in 28 centers in the United States, Europe and Israel, 237 patients with glioblastoma, tumors that had progressed or relapsed after initial treatment.

Above all, in addition to survival benefit, treatment with TTF therapy was associated with significantly better quality of life than patients receiving chemotherapy.