Dr. Dong’s team examined the role of a protein called forkhead box 01 , where his previous research has shown contributes to high levels of triglycerides in an animal model of obesity and diabetes.According to the ADA, it is estimated that 24 million Americans have type 2 diabetes, formerly called adult onset diabetes. Obesity becomes more common, however, the prevalence is increasing among children. In type 2 diabetes, the body becomes resistant to the effects of insulin, which leads to high levels of sugar in the blood.
‘But it is still unclear whether a causal relationship between chronic low-grade inflammation and the onset of insulin resistance,’ he said. ‘Other studies have shown that patients who have inflammation and diabetes, the insulin-sensitizing medications appear to reduce inflammation while anti-inflammatory drugs improve insulin sensitivity.’
In this paper, the researchers found in cultured cells and mouse experiments that Fox01 stimulates inflammatory white blood cells called macrophages, which migrate to the liver and adipose tissue or adipose tissue in insulin-resistant states, to increase the production of a cytokine called Interleukin -1 beta . The cytokines, in turn interferes with insulin signaling. Insulin inhibits Fox01 in general, creating a feedback loop in healthy tissues that helps regulate insulin levels.
The study was funded by the American Diabetes Association and the National Institutes of Health.
‘The results suggest that when there is a lack of insulin or when cells such as macrophages are resistant to his presence, there is no brake on the stimulation of IL-1B Fox01 and its interference with other signals of insulin,’ the Dr. Dong said. ‘This may explain why chronic inflammation is often associated with obesity and type 2 diabetes. In addition, a drug that acts on Fox01 might be able to better control your blood sugar
The ANC warns health professionals about the risks of shortages of drugs and includes recommendations for preventing medication errors that could result from the deficiency.