Lay eggs matured in the laboratory results in children with large offspring syndrome?

The authors of the review of the literature will be presented at the 26th Annual Meeting of the European Society of Human Reproduction and Embryology in Rome I think it might be a problem associated with the IVM process in which immature eggs are retrieved from the ovaries of a woman and matured in laboratory before being fertilized and the resulting embryos transferred into the woman. They called for caution in the use of IVM until further studies can clarify their findings.The long-term health of children born after IVM are also unknown. For reasons of safety and health of children and their mothers, we should follow the children from the moment IVM eggs are reared in the laboratory through birth and into adulthood. We must also look in detail into possible physiological effects, such as changes in blood pressure. However, we must make the public understand that, at present, no serious health problem has been observed in children born after IVM. However, all fertility clinics should share their detailed data, so you can, where appropriate, conclude that there is no reason to worry, said Dr.

He said that the possible mechanisms involved are unclear. It ‘been described in the literature that gene expression is altered in IVM eggs compared to those matured naturally in the body, may be the case that the final stages of egg development before ovulation involves events that are crucial for the development and This is not the case when they are grown in the laboratory. Another explanation could be that the preparation of the lining of the uterus is different and this may influence the development, as has been demonstrated in animal studies.

These results suggest a significant impact on the early development of the IVM procedure, said Dr. SJ Blom. The pattern of increased birth weight, more obstetric interventions and, possibly, a gestation period longer compatible with the large offspring syndrome. It can not be explained by the existence of a higher %age of women with syndrome ‘ polycystic ovaries in the IVM group *, since the birth weight of their children was not significantly different from children born after natural conception

Research has shown that patients treated in hospitals that admit a high volume of specialty patients with conditions similar fare better in the short and long term, researchers say. For example, studies show that patients undergoing brain surgery at hospitals that perform neurosurgery at least get up to 16 times the mortality rate of patients treated in hospitals performing the highest number.

We urge IVM and clinics to pool their data on obstetric and neonatal outcomes after fertility treatments because, at present, only limited data on a small number of births are available. This should allow us to look more near the health and physiology of children born after fertility treatment in order to make a more detailed assessment of the child’s health.

It Caution should be exercised before IVM large scale.