Receipt of other anti-HSV therapy, intake of grapefruit, and intake of quinine or items containing quinidine weren’t permitted through the scholarly study. All participants provided written informed consent. Study Design and Oversight The scholarly study was designed as a randomized, parallel, double-blind, placebo-controlled study by investigators at the University of Washington and by the sponsor, AiCuris, and was managed by FHI 360.Khurana, also a member of the UO's Prevention Research Institute, is lead writer of a scholarly study online ahead of print in the quarterly journal Advancement and Psychopathology. The findings, drawn from a long-term study of 382 adolescents in a mostly at-risk urban population, provide a rare, early view of adolescents' entry into the use of alcohol, marijuana and tobacco. Khurana collaborated with experts at the University of Pennsylvania and Children's Hospital of Philadelphia. They centered on 11 – to 13-year-old children as they began to explore dangerous and sensation-seeking experiences that often tag the road to independence and adulthood.