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Bristol-Myers Squibb Company (NYSE: BMY) and Pfizer (NYSE: PFE) has reported that preliminary results of phase 3 clinical trials of investigational drug apixaban compared to aspirin AVERROES (ASA) in patients who have or expect to be shown to be unsuitable for warfarin to be presented at the European Society of Cardiology Congress 2010. The results will be presented at the ‘Hot Line’ session August 31, 2010, in Stockholm, Sweden.
‘We believe this study makes an important step in 200 years to answer the question:’ How does bone sense mechanical loads? ‘Said Christopher R. Jacobs, Ph.D., co-author of the study of the Department of Mechanical Engineering at Stanford University in Stanford, California.’ Ultimately, we hope that the mechanisms identified in this study can be used to develop new treatments for bone loss and possibly many other diseases that involve primary cilia extraordinarily versatile. ‘
For patients unable to exercise osteoporosis, help may be on the road. This is because scientists have discovered exactly how the mechanical stress such as exercise, promotes bone growth. This opens the door to entirely new therapies that can fool the operating system to think you are getting a workout. The research report describing this advance is published online in The FASEB Journal.
Search by Jacobs and colleagues is based on current knowledge on the role of primary cilia (hair-like organelles that line the surface of some cells) on fluid flow in bone cells..