In a phase 2 trial previously conducted by Progenics, patients showed that methylnaltrexone after segmental colectomy received an acceleration of gastrointestinal recovery by approximately one day, on average, when compared to placebo significant improvements were seen in clinically important measures of gastrointestinal recovery. Time to first bowel movement and discharge eligibility from the hospital Methylnaltrexone was generally study study, In this study, adverse events associated with the drug treat arthritis . The most common adverse events were fever and nausea, with frequencies comparable in both groups.
About the company.Progenics Pharmaceuticals, Tarrytown, NY, is a biopharmaceutical company focusing on the development and commercialization of innovative therapeutic products to treat the unmet medical needs of patients with debilitating conditions and life-threatening diseases Client programs for symptom management and supportive care and the treatment of HIV infection and cancer addressed. The Company has three product candidates in clinical development and several others in preclinical development. The company, in collaboration with Wyeth developed methylnaltrexone for the treatment of opioid-induced side effects such as constipation and postoperative ileus. In the area of HIV – infection, A recombinant is developing the viral – entry inhibitor PRO 140, a humanized monoclonal antibody against the HIV coreceptor CCR5 . In addition, the company. Research on ProVax, a novel prophylactic HIV vaccine The company is to develop in vivo immunotherapy of prostate cancer, including directed a human monoclonal antibody-drug conjugate against prostate-specific membrane antigen , a protein found on the surface of prostate cancer cells. Progenics is developed and the development of vaccines to stimulate an immune response against PSMA. A recombinant PSMA vaccine is in phase 1 clinical trials. The company is also developing a cancer vaccine in Phase 3 clinical trials for the treatment of malignant melanoma.
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Hormonal contraception is became a safe, effective and reversible kind of birth control for men, according a recent study for the publication of in Journal of Clinical Endocrinology and Metabolism . The study revealed the combination of of testosterone and progestins suppresses production of sperm more quickly and completely potent than testosterone own. ‘It is possible for starting spermatozoa concentrations compared with reliably contraceptive in the majority, however not all men are to suppress,’said Professor Peter Y. Liu out of University of Sydney, Australian, and lead author of the study. ‘The rate of suppression is comparable with of reach after a vasectomy. ‘.