Identified protein that acts as a switch in a critical process of programmed cell death

Role of FLIP was identified after investigators bred mice that lacked both genes in the caspase-8 and RIPK3. Previous research had found that responsible for orchestrating the programmed cell death by necrosis RIPK3. Once considered a form of uncontrolled cell death, programmed necrosis is now recognized as a distinct form of cell suicide. The body is programmed both necrosis and apoptosis, the process is more common to get rid of damaged cells, dangerous or uselessThe work done by scientists to St. Jude Children Research Hospital have discovered how cells flip a switch between survival and cell death that involves a protein called FLIP.

D., author of the study and director of the Department of Immunology at St. Jude, said that work is already underway to use the results to generate new targets for cancer treatment and understanding of the fresh missteps that give rise to certain cancers as well as evidence of how some cells infected with an escape of the virus engineered to carry these threats.

The research was funded in part by the National Institutes of Health, the Canadian Institutes of Health Research, the Foundation for Medical Research and Alsace Sass.

Green said the results provide an overview of the mechanisms at work in neuroblastoma and other tumors that suffer a loss of caspase-8. Neuroblastoma originates in the cells of the sympathetic nervous system. This is the most common cancer in children strong, representing up to 10 % of all childhood cancers.

‘We believe that these results may explain the complaints of shortness of breath and fatigue in patients with pectus excavatum is not correct,’ said CHKD pediatric surgeon Robert Obermeyer, MD, assistant professor at EVMS. ‘Essentially, these patients are working harder to get the same amount of breath.’

Jude is the first author of the study. The other authors are Christopher Dillon, Ricardo Weinlich, Laura McCormick and Patrick Fitzgerald, all of St. Jude, Cristina Pop and Guy Salvesen, of Sanford-Burnham Medical Research Institute, La Jolla, and Razq Hakim, University of Toronto.

It ‘a rare thing to’ cure ‘a lethal mutation in an animal, removing another gene. When this happens, the biology shouts to us that this is important.

We have just heard, said Green.