Identification of a mechanism that may trigger the degenerative disease

Many stem cell research is necessary in mice, said Oatley, who noted that scientists who use the mouse as a model for human biology are the assumption that what they learn about the mouse is identical to what happens in a being human.Miller, MD, MS, assistant professor of medicine of emergency and author of the study.Co-authors of the study, funded by the Translational Science Institute at Wake Forest Baptist, including James W Hoekstra, MD, Doug Case, Ph.

In this study, we found that the violation of STAT3 signaling increases spermatogonial stem cell self-renewal without affecting cell proliferation in general. This indicates an alteration of the balance of spermatogonial stem cell fate decisions that inhibits differentiation in favor of self-renewal.

We have examined a mechanism that is involved in the differentiation of stem cells, and we were able to take the decision on the differentiation of self-renewal, said Jon Oatley, assistant professor of reproductive physiology, which he led. study Currently, we are at ground level – we found that in mice, and we hope that we can begin to look in human diseases, to see if this path is still true We hope that all the line, we are studying. He also, we might be able to bind to human disease.

STAT3 protein, which is active in the tissues of the body and is essential for life, regulates genes involved in cell growth and division, cell movement, and self-destruction of cells. All tissues and organs of the body are based on a specific type of differentiated cells, and these cells are constantly lost to cell death and aging. For the testes, the type of sperm cell differentiation.

Self-renewal is the process by which the result of the division of a stem cell to replicate, thus maintaining a pool of stem cells. Differentiation is when the cell division produces stem cells that become differentiated cells that maintain the function of the tissue or organ. Impairment of one of these functions in tissue stem cells and is manifested by organ failure, to decipher the mechanisms that regulate the activity of stem cells is of fundamental importance for the development of treatments for degenerative diseases.

Several key regulators of spermatogonial stem cell self-renewal have been identified, but knowledge of the molecules that control the differentiation of spermatogonial stem cells is lacking, Oatley said.

Ideally, all of us who work in mice might translate our work in humans, but the problem is that it is possible to obtain tissue samples of human origin, and it is not possible to manipulate the genetics of human resources to show what we want to learn , he said.