Rybicki said. The ability to use the model gives you an unprecedented level of reassurance and self-confidence in the procedure. Senior surgeons and radiologists involved in the five face transplantations agreed that the 3-D printed models provided superior pre-operative data and allowed complicated anatomy and bony defects to end up being better appreciated, reducing total procedure period. Less period spent in the working room is way better for overall patient outcomes, Dr. Pomahac added.‘Familial hypercholesterolemia isn’t rare,’ he noted. ‘It impacts about one in 300 to 500 people.’ Of the trials covered in the Annals review, half involved people who have familial hypercholesterolemia. Some of the additional trials centered on people who’d give up statins due to the side effects. However, it doesn’t mean the new drugs are completely safe. Martin said the main concern that has arisen in trials of the new medicines is the prospect of ‘neurocognitive effects.’ For example, some scholarly study individuals reported problems such as confusion and trouble paying attention. But, Martin said, it isn’t clear yet whether the PCSK9 inhibitors are in fact the cause.