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Neratinib is an investigational orally administered potent and irreversible dual inhibitor of HER-2 and EGFR kinases. Wyeth expects study study in a global Phase 3 program for Neratinib in advanced HER-2 – positive breast cancer later this month. – ‘Neratinib demonstrated activity against trastuzumab – resistant and trastuzumab – naive HER-2 – positive breast cancer,’Harold Burstein, a study investigator said at the Dana – Farber Cancer Institute in Boston http://tadalafilgen.com/viagra-cialis-levitra-which-is-better.html . ‘These results warrant ongoing study to see if Neratinib arsenal of arsenal of anti-HER2 drugs. Positive breast cancertrial evaluating the safety and efficacy of a daily 240 mg oral dose of Neratinib in 136 women with ErbB-2 – positive locally advanced or metastatic breast cancer The primary diagnoses evaluated. Endpoint of the open-label -arm-arm study was the 16-week progression-free survival rate . Secondary endpoints included safety, objective response rate and clinical benefit rate .

Wyeth Pharmaceuticals – Wyeth Pharmaceuticals, a division of Wyeth , announced data from an open-label Phase 2 trial with Neratinib in women with advanced HER-2 – positive early breast cancer. These data suggest that Neratinib antitumor activity in patients with advanced breast cancer positive for the ErbB – 2 receptor owns. These data were presented today in an oral session at the CTRC-AACR San Antonio Breast Cancer Symposium.

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