Gladstone scientists identify the process by which Alzheimer’s disease through the brain Creeps

Our results directly support the hypothesis that Alzheimer’s disease-related dysfunction is propagated through the neural network, with the EC as an important area of ​​vulnerability at the center, said Julie Harris, the author of the study. Although further studies are needed to better understand how events in the EC are related to Alzheimer’s disease, it is conceivable that the interference in the early stages of the EC may be a therapeutic benefit, perhaps halt the progression of the disease. It is not clear how the EC dysfunction contributes to cognitive decline in Alzheimer’s disease or vulnerability at the beginning of the EC launched the spread of dysfunction through interconnected neural networks, said the study’s lead author and director Lennart Mucke Ginder, MD . To answer these questions, we studied transgenic mice with mutant APP expressed primarily in neurons of the EC .

Altered levels of amyloid protein in the brain plays an important role in Alzheimer’s disease, a devastating neurodegenerative disease that causes progressive cognitive impairment and memory loss. Alzheimer’s disease is characterized by an abnormal accumulation of A in the brain, leading to the formation of protein aggregates that are toxic to neurons. A peptides are generated when a large protein called amyloid precursor protein is cut into small pieces.

The majority of current mouse models of Alzheimer’s disease express mutant proteins in the brain, making it difficult to identify the role of specific brain regions in Alzheimer’s disease-related dysfunction.

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Scientists at the Gladstone Institute of Neurological Disease have provided new information on the events that underlie the spread of the entire brain. The research, published in the Nov. 4 issue of the journal Neuron, follows the progression of a brain region that is affected vulnerable to disease onset in brain regions affected associates that are in later stages. The results may contribute to the design of therapeutic interventions, for the brain region that is Alzheimer’s disease may be easier than targeting different areas of the brain

The study was funded by the National Institutes of Health and a fellowship from the McBean Foundation.

One of the first brain regions affected in Alzheimer’s disease is the entorhinal cortex .

The connections between the EC and the other region of the brain called the hippocampus is essential for memory, and disruption of this circuit may play a role in memory impairment in the early stages of Alzheimer’s disease.