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Today, view more than 2 million patients mandatory warfarin the United States each year one and five per cent of do of major bleeding the year connected to having warfarin complications of be estimated on $ 1.1 billion.1. Scientists two relevant genes, VKORC1 and CYP 2C9 which up to 60 percent contribution of an individual patient its identifies with warfarin in response to variations. The wARFARIN trial is in the in adverse reactions such as increased haemorrhagic or thromboembolic events in the use of genetic information for individualized warfarin overdose. Determine from 06 to 23 trial are by Principal Investigator Elizabeth indicated that, Director of Clinical Research, Chief of Cardiology and Associate Dean of of Clinical Research out on the More House School of Medicine in Atlanta, Georgia. Ofili stated that ‘Warfarin is an important drug used to prevent blood clots. However, the adverse events are have to be reduce. This study aims contribute to how using genetic information for each patient on to administered a safer and effective dose is be understood us. ‘.