Continuous activation of the transcription factor Stat3 contributes to survival and proliferation of cancer cells. Activated Stat3 suppresses antitumor activity by stimulating immunosuppressive factors and by inhibiting the expression of chemicals levitra canada pharmacy . For antitumor immunity In addition to tumor cells themselves, Stat3 is activated in many types of immune cells present in the tumor microenvironment, such as macrophages and dendritic cells, facilitating the crosstalk between tumor cells and tumor-associated immune cells.
Drs Marcin Kortylewski and Hong Xin from the Beckman Research Institute at City of Hope in Duarte, California, Pardoll examined how IL-23 and IL-12 differentially regulated in the tumor microenvironment. The researchers found that Stat3 inhibited induced expression of IL-23 in tumor-associated macrophages, and expression of IL-12 in tumor-associated dendritic cells.
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