Extensive study of moyamoya disease reveals gender differences in key outcomes Surgery

– Five-year cumulative risk of adverse events after surgery: 8.3 % for women compared with 2.7 % in men.Males and females experienced a significant clinical improvement after surgical revascularization at a median follow-up period of 4. ‘These figures confirm the surgical revascularization as beneficial for both groups, despite the trend towards a higher incidence of postoperative adverse events in women. The importance of early assessment, clinical diagnosis and prompt surgical intervention is obviously essential, but the exact role of gender-related influences in the pathogenesis of MMD should be subjected to further studies, ‘said Dr. Khan.

The exact cause of MMD is unknown. Some genetic predisposition is evident, because it is home to 10 % of the time. There is a higher prevalence of women among the different populations MMD demographic, although gender differences in the incidence of stroke and clinical outcomes and / or without surgery were not studied.

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MMD was first described in Japan in 1956 and was known to exist mainly in Asia, although in recent years with increasing awareness, more cases are diagnosed in the United States and Europe. Once diagnosed, the goal is to prevent stroke and its effects by performing a surgery known as revascularization of extracranial intracranial bypass . This allows more blood from the scalp arteries to reach areas of the brain suffer from inadequate supply of blood.

The results of this study, gender differences in clinical presentation and treatment outcome in moyamoya disease, will be hosted by Nadia Khan, MD, 5:19 to 17:25, Tuesday, May 4, 2010, when the 78th Annual Meeting of the American Association of Neurological Surgeons in Philadelphia. Co-authors are S. Achal Achrol, MD, Raphael Guzman, MD, Robert Dodd, MD, Ph.D., Teresa Bell-Stephens, RN, and Gary K. Steinberg, MD, PhD.

The patient group at Stanford is the largest series of patients treated surgically MMD in a single institution in North America. ‘This presented a unique opportunity to clinically examine whether sex plays a role in clinical presentation and treatment outcomes after revascularization surgery on a large scale,’ said Dr. Khan.

– Women MMD patients had a risk twice as high with AIT to develop as a symptom than males.