Development of the heart affected by maternal diet and gene interactions

‘We know that poor diet and faulty genes may influence the development of both, but here we saw the two combine to cause an increased risk of health problems and more serious problems. We are excited about what this suggests that the congenital heart defects can be prevented by measures such as changing maternal nutrition. ‘‘Even though we’ve heard anecdotes of patients and physicians on Kuvan impact beyond the reduction of blood Phe, BioMarin has not formally test these purposes in a society because of the extremely short development time for Kuvan. administration of food and medicines and other regulatory authorities, and factors detailed in BioMarin filings with the Securities and Exchange Commission including, without limitation, the factors mentioned in the section ‘Risk Factors’ in BioMarin for the 2009 Annual Report on Form 10-K and the factors contained in BioMarin reports on Form 10-Q.

The power of the mother during pregnancy may be able to interact with the child inherits genes and influence the type or severity of birth defects according to research funded by the Wellcome Trust and the British Heart Foundation . The study, published in the journal Human Molecular Genetics, suggests that mothers who follow a high fat diet before and during pregnancy may be inadvertently putting their children’s health at risk.

‘These results are very important, as we have demonstrated for the first time that gene-environment interactions may influence the development of the embryo in the womb,’ said Jamie Bentham, the first author of the study.

‘The results suggest that it is good for pregnant women to stick to a balanced diet and avoid eating fatty foods too. This is good advice for everyone, especially mothers and their children.’

Professor Jeremy Pearson, Associate Medical Director of the BHF, which is partly funded the study, said:

Researchers have shown that high-fat diet and lack of Cited2 interacted, reducing the expression of another gene called PITX2. The latter gene is also required for the development of the heart and the body’s natural asymmetry.

‘This research shows that diet during pregnancy may directly influence the genes that are activated in the offspring to be born. The study was in mice, but such a link may exist in humans, leading to cases of congenital heart disease.

‘There is a growing body of research suggesting that the mother’s diet can have a lasting impact on the health of her children,’ says Professor Bhattacharya Shouma BHF. ‘It’s about when one considers the growing problem of women of reproductive age. A healthy and balanced diet is important at any time, but our research shows that this is especially true when the diet during pregnancy can potentially affect both the mother and the child. ‘

The researchers compared with those of healthy mice lacking a gene called Cited2. Cited2 deficiency of cardiac malformations in mice and humans. It ‘is also sometimes results in a type particularly serious heart defect called atrial isomerism, where the left-right asymmetry of the heart is troubled.

is the most common form of birth defects. We already know that babies born to mothers who have or are overweight are at increased risk of heart disease and other congenital malformations. It ‘also known that certain genetic mutations can lead to congenital heart disease.

However it is not known whether environmental factors such as the mother’s diet may interact with these genetic changes affect the result