Change in use of oxygen as paramedics could reduce deaths

High concentration of oxygen is commonly used by paramedics in many emergency situations for patients with dyspnea caused by acute episodes of COPD, a disease that affects over 200 million people around the world.In an accompanying editorial, retired doctors and Ronan O’Driscoll Richard Beasley warned that the systematic use of oxygen at high concentration can also be dangerous in many other medical emergencies, including heart attack and stroke.

The researchers conclude: Our results provide evidence of a high quality randomized controlled trial for the development of universal guidelines and support the recent British Thoracic Society guidelines for the treatment of acute oxygen, which recommends that oxygen must be used in concentrations sufficient to maintain adequate oxygen saturation.

The results showed significant differences in the results, according to the approach that was used.

Participants were divided into two groups – one group was treated with the standard approach to high concentrations of oxygen and the other titrated with oxygen – and the data collected over a period of 13 months between 2006 and 2007.

We have shown that in C. elegans, RRC-2 is one of the genes essential for TOR way to modulate the duration of life, says Lin Ao Allen Hsu, Ph.D., author of the study and researcher at the UM Geriatrics Center. The study also found out that the RRC-2 appears similar to a human gene, eIF4H, which controls cellular functions similar.

However, giving the high concentration of oxygen for patients with serious lung disease may lead to an accumulation of carbon dioxide in the blood, which can lead to respiratory failure.

They conclude: After over 200 years of use disorder, we must recognize that oxygen should be prescribed for defined indications for which the benefits outweigh its risks, and patient response should be monitored.

Headquartered in Australia, researchers found that the risk of death in patients with chronic obstructive pulmonary disease has been greatly reduced by using oxygen therapy titrated instead of the current common approach of the high oxygen concentration.

A confirmed COPD subgroup was retrospectively identified patients with a diagnosis of COPD during the study and this included 214 patients, 117 were treated with oxygen and the concentration of oxygen at high 97 titrated with a target range of 88-92 percent.

Patients who received high concentrations of oxygen, were significantly more likely to develop respiratory acidosis or hypercapnia when there are too many dioxide dioxide in the blood.

Hospital Tests have also shown an association between the use of oxygen at high concentrations and adverse effects such as increased mortality, length of hospital stay, need for ventilation and admission to high dependency units.