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Title:Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformationNEPHROLOGY The role of complement in Dense Deposit Disease – complement system is an important component of the innate immune system. However, inin chronic activation can deposition of complement activation products in the liver, to which tissue injury. Dense Deposit Disease is a severe kidney disease that a deficiency of factor a deficiency of factor H , a negative regulator of the complement pathway connection. Consistent with this, studies in animal models have associated activation of complement DDD. In this paper, Santiago Rodriguez de C? Rdoba and colleagues at the Centro de Investigaciones Biol? The authors believe that this finding is important in the treatment of human patients that fH spare are propose ineffective in patients with DDD, mutations mutations C3. Furthermore, this work reveals the structural features of C3, that are relevant to its inactivation, and thus can be crucial for the development of therapeutics. The proteins ofe:.
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