The study involved 13 men who ate 3.5 ounces to four servings of broccoli per week for one year and eight men who ate the same amount of peas.The men who eat broccoli a few times a week can have a lower risk than men who do not, new research suggests.
Study participants who expressed the gene showed the most advantageous genetic changes after eating broccoli.
The study is not the first to suggest that changes in diet can change our genes.
The glucosinolates are converted to other compounds known as isothiocyanates, which are widely believed to have tumor suppressor activity.
Hayes own 2007 study suggested a link between high consumption of cruciferous vegetables – especially broccoli and cauliflower – and protection against the aggressive prostate cancer.
But Mithen says that the discovery does not mean that only 50 percent of people take advantage of broccoli.
‘It goes without saying that if the genetics are among the reasons why some young people are the first victims, and genetics do not change, there is a good chance these people experience repeat victimization,’ said Castor.
The results appear in the July 2 issue of the online journal PLoS ONE.
‘It ‘important to note that directly measure the incidence of cancer,’ Richard F. Mithen, PhD, Institute of Food Research in Norwich, England, tells WebMD. ‘But the changes of genes, which we saw were consistent with a reduced risk of prostate cancer.’ Regime change genes
Studies suggest that about half of the population carries a gene called GSTM1, which can make these compounds even more protection.
As in the study in California, men who regularly ate broccoli showed more changes in gene expression indicative of a reduced risk of cancer.
‘We can too easily get into this line of research to develop a pill based on this compound or the compound to protect against cancer, but the truth is that we can never know,’ he said.
Earlier this month, researcher Dean Ornish, MD, and colleagues at the University of California, San Francisco reported that men with low risk prostate cancer have shown significant changes in gene expression when they ate a diet low fat that was high in
‘This may mean that people without the gene need to eat broccoli a little ‘more to get the same benefits,’ he said. ‘But the good news is that nobody has to eat huge quantities. A couple of servings a week seems to make a big difference.’ No clear advantage
Compared with men who ate peas four times a week, those who ate four weekly servings of broccoli for a year showed more changes in gene expression suggestive of increased protection against prostate cancer.
They found that more than 500 genes were affected, with genes associated with beneficial effects becoming more active and cancer genes, promoting properties becoming less active.
National Cancer Institute researcher Richard B. Hayes, PhD, says new research strengthens, but does not prove, the hypothesis that a healthy diet may protect against prostate cancer.
The researchers measured changes in gene expression in human prostate tissues associated with consumption of broccoli rich.
Prostate tissue samples were collected before the trial and after six and 12 months of broccoli or peas-intervention.