Adaptation to Altitude Mountain Illustrated by mice

The scientists measured fuel selection at rest and low intensity exercise in both normoxia and hypoxia .This work was done in collaboration with Peruvian scientists, Oswaldo Ramirez and Margarita Arana, from the Universidad Peruana Cayetano Heredia.

This fuel is preferably an adaptation to high altitude mice to use oxygen more efficiently than their counterparts at low altitude.

About 95 % of those in the protective ventilation group met the criteria for becoming a donor lung, compared with 54 % of those treated conventionally.

In mammals, the relative amounts of carbohydrates and fatty acids used to fuel the activities are directly related to exercise intensity, with the increasing proportion of CHO toward greater intensity of activity.

The team measured the patterns of fuel selection and metabolism of heart muscle in four species of leaf ears of mice at high altitude and low altitude in the Peruvian Andes.

The research, presented at the meeting of the Society for Experimental Biology annual Prague, is the first study to demonstrate the preferential use of carbohydrates as fuel in mammals at high altitude, where oxygen availability is low.

The increased use of CHO is intended to provide an advantage in more oxygen to save fatty acids , because it leads to ~ 15-18 percent more energy produced per mole of oxygen consumed for respiration AF.