Because little bodies don’t typically produce enough melanin to protect the skin from bright, extreme sunlight, the body activates your skin cells to create more melanin to be able to protect it. Generally, freckles fade with age, though fair-skinned people may knowledge freckling throughout life, since their bodies don’t generally produce more than enough melanin either. Basically, the lighter skin you possess, the more freckles you may expect. An age spot is a darkened spot of skin that’s usually located where the epidermis has been exposed to sun over time, and is due to an increase in pigment in certain areas of your skin. As people age, their skin becomes less supple and elastic, and fragile.ALN-TTR02 utilizes the company’s proprietary second-generation lipid nanoparticle technology using the ‘MC3′ lipid. Alnylam expects to provide data out of this study in the third quarter of 2012. Certainly, ALN-TTR02 is our lead program in this work and we be prepared to initiate a Phase II trial later this year, followed by a pivotal trial starting in 2013,’ said Akshay K. Vaishnaw, M.D., Ph.D., Senior Vice Chief and President Medical Officer of Alnylam. ‘ALN-TTR02 utilizes our proprietary second-generation LNP technology which has shown significant potency improvements in both pre-clinical and medical studies. We quite definitely look forward to our expected reporting of TTR knockdown data from the Stage I study in the 3rd quarter of this yr.’ Related StoriesResearchers identify tumor suppressor genes that drive subset of melanomasPerisylvian polymicrogyria gene foundUnderstanding how schizophrenia impacts workings of the mind’RNAi therapeutics represent a novel and thrilling approach for the treating ATTR, as this brand-new drug modality has the potential to produce a meaningful impact in the treatment of this devastating disease.