Today that it has started dosing in the also announced first-in-human clinical trial of ACHN-975, a first-in-class LpxC inhibitor that’s being developed for the treating serious infections caused by MDR Gram-negative bacterias, including pan-drug resistant Pseudomonas aeruginosa. The investigational brand-new drug application for ACHN-975 was filed with the U.S. Drug and Food Administration in the first quarter of 2012. The Stage 1 randomized, double-blind, placebo-controlled study shall evaluate the protection, tolerability, and pharmacokinetics of solitary ascending doses of ACHN-975 in healthful volunteers. The study is normally funded under a agreement award to Achaogen by the Defense Medical Advancement and Research Program.A report released this past year by the Substance Abuse and Mental Health Services Administration found er visits for nonmedical use of stimulants tripled between 2005 and 2011. Dr. Jon LaPook, chief medical correspondent for CBS Information, discussed the report and warned of the hazards these drugs pose. ‘They’re really playing Russian roulette. There may be very serious unwanted effects,’ he said. He said dangers of stimulant make use of include heart attack, stroke, psychosis and death even. LaPook spoke with pre-med college student Emily Gelber this past year about stimulant make use of at her school. Gelber said she is against using the medicines to boost academic performance adamantly. ‘One of my first checks I took in college, I found out afterwards that they had hidden cameras all over the room to monitor for cheating however the real cheating currently doesn’t result from peering over a friend’s shoulder to look at a test response,’ she said.